Synthesis , bioactivity evaluation and toxicity assessment of novel salicylanilide ester 2 derivatives as cercaricides against Schistosoma japonicum and molluscicides against
نویسندگان
چکیده
Weisi Wang, Zhiqiang Qin, Dan Zhu, Yufen Wei, Shizhu Li, Liping Duan b, # 5 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO 6 Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key laboratory of Parasitology and Vector 7 Biology of the Chinese Ministry of Health, Shanghai, China. 8 Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and 9 Technology, Shanghai, China. 10 # E-mail: [email protected]; Tel: +086 21 6437 7008. 11 AAC Accepted Manuscript Posted Online 26 October 2015 Antimicrob. Agents Chemother. doi:10.1128/AAC.01539-15 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Synthesis, Bioactivity Evaluation, and Toxicity Assessment of Novel Salicylanilide Ester Derivatives as Cercaricides against Schistosoma japonicum and Molluscicides against Oncomelania hupensis.
A series of novel salicylanilide ester derivatives were synthesized, characterized, and evaluated for cercaricidal potential against Schistosoma japonicum and molluscicidal potential against Oncomelania hupensis. Four derivatives exhibited remarkable cercaricidal activity superior to that of niclosamide. Among them, the most active compound, 4-chloro-2-((2-methoxy-4-nitrophenyl)carbamoyl)phenyl...
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